Sharma, Aditya and Pandey, Chandra M. and Matharu, Zimple and Soni,, Udit and Sapra, Sameer and Sumana, Gajjala and Pandey, Manoj K. and Chatterjee, Tathagat and Malhotra, Bansi D. (2012) Nanopatterned Cadmium Selenide Langmuir-Blodgett Platform for Leukemia Detection. Analytical Chemistry, 84 (7). 3082-3089. ISSN 0003-2700

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Abstract

We present results of the studies relating to preparation of Langmuir-Blodgett (LB) monolayers of tri-n-octylphosphine oxide-capped cadmium selenide quantum dots (QCdSe) onto indium-tin oxide (ITO) coated glass substrate. The monolayer behavior has been studied at the air water interface under various subphase conditions. This nanopattemed platform has been explored to fabricate an electrochemical DNA biosensor for detection of chronic myelogenous leukemia (CML) by covalently immobilizing the thiolterminated oligonudeotide probe sequence via a displacement reaction. The results of electrochemical response studies reveal that this biosensor can detect target DNA in the range of 10(-6) to 10(-4)M within 120 s, has a shelf life of 2 months, and can be used about 8 times. Further, this nucleic acid sensor has been found to distinguish the CML-positive and the control negative clinical patient samples.

Item Type:	Article
Additional Information:	copyright for this article belongs to M/s American Chemical Society
Subjects:	Chemistry > Analytical Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Users 27 not found.
Date Deposited:	19 Aug 2026 11:07
Last Modified:	19 Aug 2026 11:07
URI:	https://npl.csircentral.net/id/eprint/3479

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