Grewal, Harleen and Dhakate, Sanjay R. and Goyal, Amit K. and Markandeywar, Tanmay S. and Malik, Basant and Rath, Goutam (2012) Development of Transmucosal Patch Using Nanofibers. Artificial Cells, Blood Substitutes and Biotechnology , 40 (1-2). 146-150. ISSN 1073-1199

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Abstract

In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy.

Item Type:	Article
Additional Information:	Copyright for this article belongs to M/s Taylor & Francis.
Subjects:	Biotechnology & Applied Microbiology Engineering > Engineering (General) Materials Science
Divisions:	UNSPECIFIED
Depositing User:	Users 27 not found.
Date Deposited:	07 Feb 2020 10:32
Last Modified:	07 Feb 2020 10:32
URI:	http://npl.csircentral.net/id/eprint/3647

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