Singh, Satbir and Kumar, Pawan and Kaipparettu, Benny Abraham and Gupta, Bipin Kumar (2016) Eu3+ doped alpha-sodium gadolinium fluoride luminomagnetic nanophosphor as a bimodal nanoprobe for high-contrast in vitro bioimaging and external magnetic field tracking applications. RSC Advances, 6 (50). pp. 44606-44615. ISSN 2046-2069

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Abstract

Herein, we introduce a novel strategy for the synthesis of Eu3+ doped alpha-sodium gadolinium fluoride (alpha-NaGd0.88F4:Eu0.12(3+)) based luminomagnetic nanophosphors using a hydrothermal route. The synthesized nanophosphor has exceptional luminescent and paramagnetic properties in a single host lattice, which is highly desirable for biomedical applications. This highly luminescent nanophosphor with an average particle size similar to 5 +/- 3 nm enables high-contrast fluorescent imaging with decreased light scattering. In vitro cellular uptake is shown by fluorescent microscopy that envisages the characteristic hypersensitive red emission of Eu3+ doped alpha-sodium gadolinium fluoride centered at 608 nm (D-5(0)-F-7(2)) upon 465 nm excitation wavelength. No apparent cytotoxicity is observed. Furthermore, time-resolved emission spectroscopy and SQUID magnetic measurements successfully demonstrate a photoluminescence decay time of microseconds and an enhanced paramagnetic behavior, which holds promise for the application of nanophosphors in biomedical studies. Hence, the obtained results strongly suggest that this nanophosphor could be potentially used as a bimodal nanoprobe for high-contrast in vitro bioimaging of HeLa cells and external magnetic field tracking applications of luminomagnetic nanophosphors using permanent magnet.

Item Type:	Article
Additional Information:	Copyright for this article belongs to M/s Royal Society of Chemistry.
Subjects:	Chemistry
Divisions:	UNSPECIFIED
Depositing User:	Dr. Rajpal Walke
Date Deposited:	17 Nov 2017 11:44
Last Modified:	17 Nov 2017 11:44
URI:	http://npl.csircentral.net/id/eprint/2209

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