Upadhyaya, Laxmi and Singh, Jay and Agarwal, Vishnu and Tewari, Ravi Prakash (2013) Biomedical applications of carboxymethyl chitosans. Carbohydrate Polymers , 91 (1). pp. 452-466. ISSN 0144-8617

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Abstract

This review outlines the recent developments on carboxymethyl chitosan-based bio-medical applications. Carboxymethyl chitosan, a water soluble derivative of chitosan, with enhanced biological and physicochemical properties compared to chitosan, has emerged as a promising candidate for different biomedical applications. Introducing small chemical groups like carboxymethyl to the chitosan structure can drastically increase the solubility of chitosan at neutral and alkaline pH values without affecting their characteristic properties. Due to improved biocompatibility, high moisture retention ability more viscosity and enhanced antimicrobial property of carboxymethyl chitosan than chitosan makes it promising candidate for hydrogels and wound healing applications. The biodegradability and biocompatibility of carboxymethyl chitosan has significant interest with application as biomaterial for tissue engineering. Apart from this, the easy of carboxymethyl chitosan can be easily processed into nanoparticles so it has shown promise for drug delivery, bioimaging, biosensors and gene therapy applications. The contribution of carboxymethyl chitosan to green chemistry in the recent years has also been given in detail. This review will focus on preparative methods and physicochemical and biological properties of carboxymethyl chitosan with particular emphasis on biomedical and pharmaceutical applications of this derivative of chitosan.

Item Type:	Article
Additional Information:	copyright for this article belongs to M/s Elsevier
Subjects:	Chemistry > Organic Chemistry Chemistry > Applied Chemistry Polymer Science
Divisions:	UNSPECIFIED
Depositing User:	Users 27 not found.
Date Deposited:	19 Aug 2026 10:40
Last Modified:	19 Aug 2026 10:40
URI:	https://npl.csircentral.net/id/eprint/3327

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