Singh, Painal and Jangir, Deepak Kumar and Mehrotra, Ranjana and Kandpal, H. C. (2008) Determination of Moisture Content in 5-Fluorouracil using Diffuse Reflectance Infrared Spectroscopy. In: 2nd International Conference on Perspectives in Vibrational Spectroscopy, FEB 24-28, 2008 , Mar Ivanios Coll, Thiruvananthapuram, INDIA.

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Abstract

Determination of moisture content in pharmaceuticals is very important, as moisture is mainly responsible for the degradation of drugs. The degraded drug has not only reduced efficacy but is also hazardous for health. The objective of the present work is to replace the Karl Fischer (KF) titration method used for moisture analysis with a method that is rapid, involves no toxic materials and is more effective. Diffuse reflectance infrared spectroscopy, which is explored as a potential alternate for various applications. is investigated for moisture analysis in 5-Fluorouracil, an anticancer drug.

Item Type:	Conference or Workshop Item (Paper)
Subjects:	Spectroscopy
Divisions:	UNSPECIFIED
Depositing User:	Ms Neetu Chandra
Date Deposited:	05 Apr 2013 08:10
Last Modified:	05 Apr 2013 08:10
URI:	http://npl.csircentral.net/id/eprint/970

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