Arora, Varun and Sood, Anku and Shah, Jyoti and Kotnala, R. K. and Jain, Tapan K. (2017) Synthesis and characterization of pectin-6-aminohexanoic acid-magnetite nanoparticles for drug delivery. Materials Science and Engineering: C , 80 ( ). pp. 243-2. ISSN 0928-4931

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Abstract

In this study, we have synthesized magnetic nanocomposites of magnetite nanoparticles coated with 6-aminohexanoic acid and pectin (MAP). The size of the aqueous dispersion of the nanocomposites was 147 nm with a Polydispersity index (PDI) of 0.32, and the nanocomposites were stable in NaCl up to a concentration of 0.45% (w/v) after which they aggregated. The dispersion of the nanocomposites was stable in Dulbecco's Modified Eagle's medium (DMEM) in the presence of 5 and 10% fetal bovine serum (FBS). Curcumin was used as a model drug to evaluate the potential of the nanocomposites for drug delivery applications. The release behavior of curcumin from the nanocomposites showed a biphasic pattern with initial burst release followed by a slow release, and the size of the aqueous dispersion of curcumin loaded nanocomposites was 159 nm with a PDI of 0.34.

Item Type:	Article
Additional Information:	Copyright for this article belongs to M/S Elsevier.
Subjects:	Materials Science
Divisions:	UNSPECIFIED
Depositing User:	Users 27 not found.
Date Deposited:	29 Apr 2019 07:56
Last Modified:	29 Apr 2019 07:56
URI:	http://npl.csircentral.net/id/eprint/2900

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