Sood, Ankur and Arora, Varun and Shah, Jyoti and Kotnala, R. K. and Jain, Tapan K. (2017) Multifunctional gold coated iron oxide core-shell nanoparticles stabilized using thiolated sodium alginate for biomedical applications. Materials Science and Engineering: C , 80. pp. 274-281. ISSN 0928-4931

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Abstract

In this paper we report synthesis of aqueous based gold coated iron oxide nanoparticles to integrate the localized surface plasma resonance (SPR) properties of gold and magnetic properties of iron oxide in a single system. Iron oxide-gold core shell nanoparticles were stabilized by attachment of thiolated sodium alginate to the surface of nanoparticles. Transmission electron microscope (TEM) micrograph presents an average elementary particle size of 8.1 +/- 2.1 nm. High resolution TEM (HR-TEM) and X-ray photon spectroscopy further confirms the presence of gold shell around iron oxide core. Gold coating is responsible for reducing saturation magnetization (M-s) value from similar to 41 emu/g to similar to 24 emu/g - in thiolated sodium alginate stabilized gold coated iron oxide core-shell nano particles. The drug (curcumin) loading efficiency for the prepared nanocomposites was estimated to be around 7.2 wt (72 mu g drug/mg nanoparticles) with encapsulation efficiency of 72.8%. Gold-coated iron oxide core shell nanoparticles could be of immense importance in the field of targeted drug delivery along with capability to be used as contrast agent for MRI & CT.

Item Type:	Article
Additional Information:	Copyright for this article belongs to M/s Elsevier.
Subjects:	Materials Science
Divisions:	UNSPECIFIED
Depositing User:	Users 27 not found.
Date Deposited:	12 Nov 2018 07:43
Last Modified:	12 Nov 2018 07:43
URI:	http://npl.csircentral.net/id/eprint/2799

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