Sharmaa, Parul and Mathur, Garima and Dhakate, Sanjay R. and Chand, Subhash and Goswami, Navendu and Sharma, Sanjeev K. and Mathur, Ashwani (2016) Evaluation of physicochemical and biological properties of chitosan/poly (vinyl alcohol) polymer blend membranes and their correlation for Vero cell growth. Carbohydrate Polymers, 137. pp. 576-583. ISSN 0144-8617

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The blend membranes with varying weight ratios of chitosan/poly (vinyl alcohol) (CS/PVA) (1:0, 1:1, 1:2.5, 1.5:1, 1.5: 2.5) were prepared using solvent casting method and were evaluated for their potential application in single-use membrane bioreactors (MBRs). The physicochemical properties of the prepared membranes were investigated for chemical interactions (FTIR), surface morphology (SEM), water uptake, protein sorption (q(e)), ammonia sorption and growth kinetics of Vero cells. CS/PVA blend membrane having weight ratio of 1.5:1 had shown enhanced membrane flexibility, reduced water uptake, less protein sorption and no ammonium sorption compared to CS membrane. This blend membrane also showed comparatively enhanced higher specific growth rate (0.82/day) of Vero cells. Improved physicochemical properties and growth kinetics obtrude CS/PVA (1.5:1) as a potential surface for adhesion and proliferation with possible application in single use membrane bioreactors. Additionally, new insight explaining correlation between water holding (%) of CS/PVA (1.5:1) blend membrane and doubling time (t(d)) of Vero cells is proposed.

Item Type: Article
Additional Information: Copyright for this article belongs to M/s Elsevier.
Uncontrolled Keywords: Chitosan Membrane Growth kinetics Sorptiona
Subjects: Chemistry > Organic Chemistry
Chemistry > Polymer Science
Chemistry > Applied Chemistry
Depositing User: Dr. Rajpal Walke
Date Deposited: 20 Nov 2017 07:06
Last Modified: 20 Nov 2017 07:06

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