Tiwari, A and Prabaharan, M. (2009) An amphiphilic nanocarrier based on guar gum-graft-poly(epsilon-caprolactone) for potential drug-delivery applications. Journal of Biomaterials Science, 21 (6). pp. 937-949. ISSN 0920-5063

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Amphiphilic guar gum grafted with poly(epsilon-caprolactone) (GG-g-PCL) was fabricated as a drug-delivery carrier using microwave irradiation. The structure of the GG-g-PCL co-polymer was characterized by (1)H-NMR spectroscopy. By microwave irradiation, GG-g-PCL with high grafting percentage (>200%) was obtained in a short reaction time. The GG-g-PCL co-polymer is capable of self-assembling into nanosized spherical micelles in aqueous solution with the diameter of around 75-135 nm and 60-100 nm, as determined by DLS and TEM, respectively. The critical micelle concentration (CMC) of GG-g-PCL was found to be approx. 0.56 mg/l in a phosphate buffer solution. The drug-release profile showed that the GG-g-PCL micelles provided an initial burst release followed by a sustained release of the entrapped hydrophobic model drug, ketoprofen, over a period of 10-68 h. Under physiological conditions, the GG-g-PCL co-polymer hydrolytically degraded into lower-molecular-weight fragments within a 7-week period. These results suggest that the GG-g-PCL micelles could be used as a nanocarrier for in vitro controlled drug delivery.

Item Type: Article
Subjects: Biophysics
Materials Science
Depositing User: Ms Neetu Chandra
Date Deposited: 06 Feb 2012 08:27
Last Modified: 13 Feb 2012 12:26
URI: http://npl.csircentral.net/id/eprint/20

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