Singh, Chandan and Pandey, M. K. and Biradar, A. M. and Srivastava, A. K. and Sumana, Gajjala (2014) A bienzyme-immobilized highly efficient niobium oxide nanorod platform for biomedical application. RSC Advances , 4 (30). pp. 15458-15465. ISSN 2046-2069

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Electrophoretically deposited niobium oxide nanorods have been utilized to fabricate a high performance biosensor for specific cholesterol detection. The orthorhombic structure of the Nb2O5 platform has resulted in the stable and excellent characteristics of the fabricated biosensor. This biosensor has been able to detect cholesterol selectively in a wide detection range [25-500 mg dl(-1)] with a sensitivity of 0.267 mu A/ mg dl(-1) cm(-2), has a re-usability of 10 times and stability for 6 months, due to the immobilization of the bienzyme onto the matrix, assisted by the intrusion in the Nb2O5 nanorods. The low Michaelis-Menten constant (0.07 mg dl(-1)) for the biosensor indicates a higher affinity of the bienzyme towards cholesterol. The sensor has also been validated with clinical samples.

Item Type: Article
Additional Information: Copyright for this article belongs to M/S RSC.
Subjects: Chemistry
Depositing User: Dr. Rajpal Walke
Date Deposited: 07 Sep 2015 10:12
Last Modified: 07 Sep 2015 10:12

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